🔥Hot Topics Today: -Targeting CDK46 in breast [email protected]

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• 2025-02-10 18:18 Pseudo acute kidney injury in patients receiving CDK4/6 inhibitors - Nature.com
• 2025-02-06 14:26 Real-world effectiveness of CDK4/6i in first-line treatment of HR+/HER2-advanced/metastatic breast cancer: Updated systematic review - Frontiers
• 2024-12-14 08:00 Machine learning model predicts CDK4/6 inhibitor effectiveness in metastatic breast cancer - News-Medical.Net
• 2024-11-27 08:00 Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer - Nature.com
• 2025-01-10 08:00 BCRF-Supported Research Sheds Light on Why Patients Stop Responding to CDK4/6 Inhibitors - Breast Cancer Research Foundation
• 2024-05-03 07:00 CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication - Science
• 2024-12-19 08:00 Can AI Tool Guide CDK4/6 Inhibitor Use in Breast Cancer? - Medscape
• 2024-11-06 08:00 Figure 1. AKT-protein kinase B, CDK4/6-cyclin dependent kinase 4 and 6,... - ResearchGate
• 2024-12-20 08:00 Sticking With CDK4/6 Inhibitors for Breast Cancer Wins in Post-Progression Setting - Medpage Today
• 2024-09-18 14:13 ESMO Advanced Course on CDK4/6 Inhibitors in HR+/HER2- BC - OncologyPRO
• 2024-12-13 08:00 Incyclix Bio Announces Interim Clinical Data from the Phase - GlobeNewswire
• 2024-11-27 08:00 SONIA trial demonstrates cost-effective treatment approach for advanced breast cancer - News-Medical.Net
• 2024-07-24 07:00 Comparative cost-effectiveness analysis of CDK4/6 inhibitors in the first-line treatment of HR-positive and HER2-negative advanced breast cancer: a Markov's model-based evaluation - Frontiers
• 2024-09-25 07:00 CDK4 is co-amplified with either TP53 promoter gene fusions or MDM2 through distinct mechanisms in osteosarcoma - Nature.com
• 2024-06-14 02:26 Dose modifications and management of CDK4/6 inhibitors. - ResearchGate
• 2024-11-27 08:00 Toxicity and costs of cancer treatment reduced by deferring CDK4/6 inhibitor use - Nature.com
• 2024-06-20 07:00 Real-world effectiveness of CDK 4/6 inhibitors in estrogen-positive metastatic breast cancer - Nature.com
• 2024-08-02 07:00 Copy number alterations in metastatic and early breast tumours: prognostic and acquired biomarkers of resistance to CDK4/6 inhibitors | British Journal of Cancer - Nature.com
• 2024-05-22 07:00 Osimertinib and palbociclib in an EGFR -mutated NSCLC with primary CDK4 amplification after progression under osimertinib - Nature.com
• 2024-10-04 07:00 Correction: CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism - Nature.com
• 2024-09-03 07:00 CDK4/6 inhibitors show promise for pediatric high-grade glioma treatment - News-Medical.Net
• 2024-12-11 08:00 Elacestrant Shows Tolerability in Combination With CDK4/6, PI3K Inhibitors in Advanced ER+ Breast Cancer - OncLive
• 2024-12-12 08:00 Kaklamani on Elacestrant for CDK4/6 Inhibitor-Naive ER+ Breast Cancer Treatment - Targeted Oncology
• 2024-04-11 14:15 Fig. 1 Mechanism of action of CDK4/6 inhibitors -Inhibition of G1/S... - ResearchGate
• 2024-10-31 07:00 CDK4/6 Inhibition in Peritoneal Mucinous Carcinomatosis With GNAS Mutation - The ASCO Post
• 2024-12-10 08:00 Dr Bardia on T-DXd Efficacy By Pace of Prior CDK4/6 Inhibitor Progression in Breast Cancer - OncLive
• 2024-04-15 07:00 Association between CDK4/6 inhibitors and drug-related osteonecrosis of the jaw: A pharmacoepidemiological study using the FDA Adverse Events Reporting System - Wiley Online Library
• 2025-01-28 13:18 Clinical Perspectives: Use of CDK4/6i After CDK4/6i - OncLive
• 2024-08-26 07:00 CDK4/6 Inhibitors, ADCs, and PI3K Inhibitors Individualize HR+ Breast Cancer Management - OncLive
• 2024-09-25 07:00 Adjuvant Ribociclib Approval Expands Access to CDK4/6 Inhibition in High-Risk HR+/HER2– Breast Cancer - OncLive
• 2024-12-15 08:00 Elacestrant Plus CDK4/6i May Optimize ESR1+ Breast Cancer Outcomes - Cancer Network
• 2023-08-11 07:00 Radiomic predicts early response to CDK4/6 inhibitors in hormone receptor positive metastatic breast cancer - Nature.com
• 2024-09-04 07:00 Park and Graff Explore the Evolving Role of CDK4/6 Inhibitors in Metastatic Breast Cancer - OncLive
• 2024-11-14 08:00 ASCO Recommends ESR1 Mutation Testing for Certain Metastatic Breast Cancers - Breastcancer.org
• 2025-01-02 08:00 The 2024 San Antonio Breast Cancer Symposium: Key Takeaways - Breastcancer.org
• 2024-04-25 07:00 ESR1-Driven Resistance to CDK4/6 Inhibitors in Breast Cancer Thwarted by SERDs - Medpage Today
• 2024-06-14 07:00 ASCO Updates Guidelines for CDK4/6 Inhibitor Use in Early Breast Cancer - Oncology News Central
• 2024-06-24 07:00 Treating Advanced Breast Cancer After Progression on CDK4/6 Inhibitors - Medpage Today
• 2023-09-13 07:00 Determinants of response to CDK4/6 inhibitors in the real-world setting - Nature.com
• 2024-09-17 07:00 FDA Expands Approval of Ribociclib to Early Breast Cancer - Medpage Today
• 2023-09-15 07:00 Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation - JCI
• 2024-05-20 07:00 Dr Shen on Adjuvant CDK4/6 Inhibitors in HR+/HER2– Breast Cancer - OncLive
• 2024-02-07 08:00 Comparative overall survival of CDK4/6 inhibitors in combination with endocrine therapy in advanced breast cancer - Nature.com
• 2024-12-13 08:00 Agendia Unveils New Real-World-Evidence from FLEX, Highlighting the Expanding Utility of MammaPrint® and BluePrint® for Predicting Neoadjuvant Chemosensitivity and Potential Resistance to CDK4/6 Inhibition in Early-Stage Breast Cancer at SABCS 20 - BioSpace
• 2025-01-02 08:00 Phase 3 Palbociclib Data Are “Immediately Practice-Changing” in Advanced Breast Cancer - Oncology News Central
• 2024-04-18 07:00 CDK2 inhibitors at AACR: An answer to CDK4/6 resistance? - BioCentury
• 2024-08-22 07:00 The HR-Positive Breast Cancer Treatment Paradigm Sits on the Cusp of Significant Shifts - OncLive
• 2024-09-18 07:00 Novartis’ Kisqali combination granted FDA approval for early breast cancer patients - PMLiVE
• 2024-12-12 08:00 SABCS: Under siege from competitors, Pfizer's Ibrance scores in double-positive breast cancer - FiercePharma
• 2023-12-02 08:00 Ratios of monocytes and neutrophils to lymphocytes in the blood predict benefit of CDK4/6 inhibitor treatment in metastatic breast cancer | Scientific Reports - Nature.com
• 2023-10-26 07:00 Late onset toxicities associated with the use of CDK 4/6 inhibitors in hormone receptor positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) metastatic breast cancer patients: a multidisciplinary, pan-EU position paper regarding their opti - Frontiers
• 2023-06-29 07:25 CDK4/6 Inhibitor PD0332991 in Glioblastoma Treatment: Does It Have a Future? - Frontiers
• 2021-08-12 07:00 Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer - Nature.com
• 2025-01-07 00:57 Komal Jhaveri, MD, FACP on The Phase III EMBER Trial - The ASCO Post
• 2024-05-01 07:00 Pepper Bio spices up pipeline with $135M deal for G1 Therapeutics' CDK4/6 inhibitor - Fierce Biotech
• 2023-06-28 07:00 Outcomes and toxicity of concurrent CDK4/6 inhibitor and locoregional radiotherapy for patients with de novo metastatic breast cancer - Beddok - 2023 - International Journal of Cancer - Wiley Online Library
• 2011-02-18 08:00 MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone - Nature.com
• 2019-06-03 07:00 Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology - Nature.com
• 2023-03-17 13:31 Ongoing adjuvant phase 3 trials with CDK4/6 inhibitors in luminal early breast cancer - ResearchGate
• 2021-10-06 07:00 Combo of Ribociclib, Letrozole Improves Survival in Advanced Breast Cancer - NCI Cancer Bulletin
• 2024-12-10 08:00 Scorpion Therapeutics Provides Clinical Program Updates for Its Mutant-Selective PI3Kα Inhibitor STX-478 - BioSpace
• 2009-03-17 07:00 Crystal structure of human CDK4 in complex with a D-type cyclin - pnas.org
• 2023-06-12 07:00 First- vs. second-line CDK4/6 inhibitor use fails to benefit breast cancer subgroup - Healio
• 2023-10-06 07:00 Optimal Position of CDK4/6 Inhibitors: The SONIA Trial - Pharmacy Times
• 2022-03-03 19:19 The structure of CDK4/cyclin D3 has implications for models of CDK activation - pnas.org
• 2023-07-05 07:00 NCI study challenges long-held beliefs about cell division - NCI Cancer Bulletin
• 2021-02-03 08:00 Circulating tumor DNA dynamics in advanced breast cancer treated with CDK4/6 inhibition and endocrine therapy - Nature.com
• 2024-04-12 07:00 Examining the Evolution of Treatment With Targeted Agents in Metastatic Breast Cancer - OncLive
• 2022-02-08 08:00 The Role of the CDK4/6 Inhibitor Ribociclib in Locally Advanced and Oligometastatic Hormone Receptor Positive, Her2 Negative, Advanced Breast Cancer: Case Series and Review of the Literature - Frontiers
• 2013-10-14 07:00 3D-QSAR and 3D-QSSR studies of thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysis - Nature.com
• 2020-06-09 07:00 A Protracted Course of COVID19 Infection in a Metastatic Breast Cancer Patient During CDK4/6 Inhibitor Therapy - Frontiers
• 2023-08-10 07:00 Managing Toxicities and Adverse Events of CDK 4/6 Inhibitors - OncLive
• 2023-02-06 08:00 Treatment after Progression on CDK4/6 Inhibitors - OncLive
• 2023-01-11 08:00 A Japanese case of familial malignant melanoma with germline CDK4 variant incidentally diagnosed by cancer genome profiling - Nature.com
• 2015-09-04 07:00 Prognostic value of HMGA2 CDK4 , and JUN amplification in well-differentiated and dedifferentiated liposarcomas - Nature.com
• 2018-10-08 07:00 Phase II trial of palbociclib in patients with metastatic urothelial cancer after failure of first-line chemotherapy - Nature.com
• 2021-01-06 08:00 A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC-042) - Wiley Online Library
• 2023-11-18 19:44 Retrospective and real-world evidence on CDK 4/6 inhibitors in elderly patients. - ResearchGate
• 2015-05-05 07:00 A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis - Wiley Online Library
• 2017-04-05 07:00 Are CDK4/6 Inhibitors Transforming Breast Cancer Treatment? - Breast Cancer Research Foundation
• 2021-09-06 07:00 New Therapeutic Method Combined with Synthetic CDK4/6 Inhibitors for Refractory Cancers - Asia Research News
• 2022-07-22 07:00 An Integrated Pharmacological Counselling Approach to Guide Decision-Making in the Treatment with CDK4/6 Inhibitors for Metastatic Breast Cancer - Frontiers
• 2022-03-15 04:25 Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. - pnas.org
• 2022-02-04 08:00 Common Adverse Events With CDK4/6 Inhibitors - Targeted Oncology
• 2011-04-14 07:00 CDK4 and cyclin D1 allow human myogenic cells to recapture growth property without compromising differentiation potential | Gene Therapy - Nature.com
• 2018-12-12 08:00 Metastatic Breast Cancer: CDK4/6 Inhibitors - AJMC.com Managed Markets Network
• 2023-10-06 06:44 MONALEESA-2 patient selection. ESS reflects sample size after... - ResearchGate
• 2018-12-12 08:00 Benefits and Challenges of CDK4/6 Inhibitors - AJMC.com Managed Markets Network
• 2023-03-02 08:00 Continuing CDK4/6 Inhibition at Progression of HR+ Metastatic Breast Cancer - OncLive
• 2023-10-20 07:00 Neurocognitive impairment in females with breast cancer treated with endocrine therapy and CDK4/6 inhibitors: a pharmacovigilance study using the World Health Organization’s database - Frontiers
• 2022-07-15 07:00 Myeloprotective Benefit of CDK4/6 Inhibition in ES-SCLC - OncLive
• 2017-08-30 07:00 Cell cycle inhibitors boost tumour immunogenicity - Nature.com
• 2023-10-27 07:00 #ESMO23: Expert report on adjuvant CDK4/6 inhibitors in EBC - OncologyPRO
• 2020-03-20 07:00 Loss of copy of MIR1-2 increases CDK4 expression in ileal neuroendocrine tumors - Nature.com
• 2023-10-05 07:00 CDK4/6 & PARP Inhibitors for Early-Stage Breast Cancer - Cancer Network
• 2024-01-30 08:00 Enhancing the Functionality of Pancreatic Beta Cells in Type 2 Diabetes - NewYork-Presbyterian
• 2017-09-29 07:00 Cell cycle inhibitors boost tumour immunogenicity - Nature.com
• 2021-06-28 07:00 Drug induced vitiligo‐like depigmentation from a CDK 4/6 inhibitor - Wiley Online Library
• 2021-10-13 07:00 FDA Approves Verzenio® (abemaciclib) as the First and Only CDK4/6 Inhibitor for Certain People with HR+ HER2- High Risk Early Breast Cancer - Investors | Eli Lilly and Company
• 2023-06-15 07:00 When it comes to treating resistant breast cancer, 2 drugs may be better than 1 - University of Colorado Boulder

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